Substance-Specific Considerations
Alcohol
Alcohol exposure in early pregnancy poses a significant neurodevelopmental
risk, and there is no known safe level of use during pregnancy. Because
organogenesis occurs before many individuals recognize pregnancy,
preconception counselling is critical. Management should integrate screening,
brief intervention, relapse prevention planning, and coordination of care when
dependence is present.
Key Preconception Actions
- Screen routinely for alcohol use
- Encourage abstinence when planning pregnancy
- Provide brief counselling and relapse prevention planning
- Assess dependence and coordinate care if needed
- Screen for co-occurring mental health conditions
Clinical Pearl: No safe amount, no safe time, no safe type of
alcohol during pregnancy.
Summary of Alcohol Use Interventions in Pregnancy
|
Intervention Category
|
Key Components
|
Evidence and Effectiveness
|
Clinical Considerations
|
|
Universal Screening (Core Intervention)
|
Routine screening at preconception and every antenatal visit; assess
frequency, quantity, binge patterns
|
Strong evidence that screening reduces alcohol-exposed pregnancies
|
Universal, nonjudgmental screening recommended as standard prenatal
care
|
|
Brief Behavioural Counselling
|
Clear advice that no alcohol is safe; personalized risk feedback; goal
setting focused on abstinence
|
Proven to reduce alcohol use and alcohol-exposed pregnancies
|
First-line intervention should be delivered early and repeated
|
|
Motivational Interviewing (MI)
|
Empathy, autonomy support, exploration of ambivalence, intrinsic
motivation
|
Effective for women uncertain about abstinence
|
Recommended for ambivalence or continued use
|
|
Preconception Counseling
|
Advise abstinence when planning pregnancy; address misconceptions
about “safe” drinking
|
Prevents early embryonic exposure
|
Preconception abstinence due to early fetal vulnerability is
emphasized
|
|
Management of Alcohol Use Disorder (AUD)
|
Referral to addiction and mental health services; psychosocial
treatment
|
Improves maternal stability and pregnancy outcomes
|
Integrated, multidisciplinary care encouraged; pharmacotherapy
generally avoided
|
|
Pharmacotherapy for AUD
|
Medications for AUD
|
Insufficient safety data in pregnancy
|
Not routinely recommended
|
|
Partner and Social Environment Interventions
|
Address partner drinking; promote alcohol-free environments
|
Reduces relapse and ongoing exposure
|
Family- and partner-inclusive counselling
|
|
Public Health Messaging
|
“No safe amount, no safe time, no safe type”
|
Improves awareness and prevention
|
Consistent with prevention messaging
|
|
Postpartum Relapse Prevention
|
Continued screening; counseling; mental health support
|
Reduces relapse risk postpartum
|
Ongoing substance use assessment postpartum is recommended
|
|
Trauma and Violence-Informed Care
|
Nonjudgmental, culturally safe approach
|
Improves disclosure and engagement
|
Explicitly supported by SOGC to reduce stigma
|
For more information, see SOGC Guideline No. 405: Screening and Counselling for Alcohol Consumption DuringPregnancy.
Nicotine and Tobacco (Including Vaping)
Nicotine exposure affects fertility, placental development, fetal growth and
increases the risk of stillbirth. Preconception cessation or reduction
improves both maternal and pregnancy outcomes. Counselling should address all
nicotine products, including vaping and second-hand exposure, and include
behavioural and pharmacologic supports when indicated.
Key Preconception Actions
- Support cessation prior to conception
- Address all nicotine products, including vaping
- Offer behavioural counselling and cessation supports
-
Consider nicotine replacement therapy if behavioural supports are
insufficient
Clinical Pearl: Stopping smoking before pregnancy
significantly improves maternal and fetal outcomes.
Strategies for Smoking Cessation Interventions
|
Intervention Category
|
Key Components
|
Evidence and Effectiveness
|
Clinical Considerations in Pregnancy
|
|
Behavioural Counselling (Core Intervention)
|
≥15-minute sessions; repeated throughout pregnancy; education on
risks, withdrawal symptoms, triggers, coping strategies; relapse
prevention
|
Strong evidence from clinical trials shows increased quit rates
|
First-line intervention; should begin early and continue antenatally
and postnatally
|
|
Cognitive Behavioural Therapy (CBT)
|
Self-monitoring, craving management, stress reduction, goal setting,
problem-solving, and self-efficacy building
|
Demonstrated improvement in cessation rates among pregnant women
|
Effective for managing cravings, stress, and relapse risk
|
|
Motivational Interviewing (MI)
|
Empathy, autonomy support, exploring ambivalence, and strengthening
intrinsic motivation
|
Effective for women ambivalent or resistant to quitting
|
Particularly useful when readiness to quit is low
|
|
Nicotine Replacement Therapy (NRT)
|
Patch (daytime) + short-acting forms (gum/lozenge); lowest effective
dose; remove patch at night if appropriate
|
Modestly increases quit rates; safer than continued smoking
|
Consider when counselling alone fails; it requires informed discussion
of risks and benefits
|
|
Bupropion
|
Antidepressant with smoking cessation properties
|
Limited and low-quality evidence in pregnancy
|
Not routinely recommended; safety data insufficient
|
|
Varenicline
|
Nicotinic receptor partial agonist
|
Insufficient safety data in pregnancy
|
Not recommended during pregnancy or breastfeeding
|
|
Digital Interventions (mHealth)
|
Text messaging, computer-based programs, tailored content;
self-efficacy and coping support
|
Effective as adjuncts, text-based interventions show benefit
|
Useful for women underutilizing traditional services; best combined
with personal support
|
|
Electronic Cigarettes (E-cigarettes)
|
Nicotine delivery without combustion
|
Insufficient evidence on fetal safety; lower CO exposure than
cigarettes
|
Not recommended; may be considered only as harm reduction when other
options fail (jurisdiction-dependent)
|
|
5As / 3As Framework
|
Ask, Advise, Assess, Assist, Arrange follow-up (or Ask, Advise, Act)
|
Widely endorsed best-practice model
|
Should be applied at every antenatal visit
|
|
5Rs (Low Motivation)
|
Relevance, Risks, Rewards, Roadblocks, Repetition
|
Effective for enhancing motivation
|
Appropriate when women are unwilling or not ready to quit
|
|
Second-hand Smoke Reduction
|
Partner/family counselling; smoke-free homes and vehicles
|
Reduces fetal and neonatal risks
|
Involve partners and household members
|
|
Postpartum Relapse Prevention
|
Continued counselling; breastfeeding support; coping strategies; focus
on intrinsic motivation
|
High relapse rates without support
|
Counselling should extend into the postpartum period
|
For more information, see SOGC Guideline No. 349-Substance Use in Pregnancy.
Cannabis
Cannabis use is increasingly normalized, yet early exposure may affect
placental function and neurodevelopment. Risk perception often influences use
patterns, making anticipatory counselling essential. Providers should address
misconceptions, support cessation before conception and integrate mental
health and substance use care where appropriate.
Key Preconception Actions
- Screen routinely for cannabis use
- Address misconceptions about safety
- Encourage cessation before conception
- Integrate mental health support when needed
Clinical Pearl: Cannabis is often perceived as low risk;
anticipatory counselling improves cessation.
Summary of Cannabis Use Interventions in Pregnancy
|
Intervention Category
|
Key Components
|
Evidence and Effectiveness
|
Clinical Considerations
|
|
Universal Screening (Core Intervention)
|
Routine screening at preconception and each antenatal visit; assess
frequency, route, potency
|
Improves identification and counselling opportunities
|
Universal, nonjudgmental screening
|
|
Brief Behavioural Counselling
|
Clear advice that no cannabis use is safe; education on fetal risks;
goal of abstinence
|
Effective in reducing prenatal exposure
|
First-line intervention in pregnancy
|
|
Motivational Interviewing (MI)
|
Explore ambivalence; address safety misconceptions; support intrinsic
motivation
|
Useful when cannabis use is normalized or perceived as low risk
|
Recommended for continued use or ambivalence
|
|
Preconception Counseling
|
Advise discontinuation prior to conception
|
Prevents early fetal and placental exposure
|
Emphasis on abstinence when planning pregnancy
|
|
Management of Cannabis Use Disorder
|
Referral to addiction and mental health services; psychosocial
therapies
|
Improves maternal stability and engagement
|
Pharmacologic treatment is not recommended
|
|
Pharmacotherapy
|
None approved for cannabis cessation in pregnancy
|
Insufficient safety and efficacy data
|
Not recommended
|
|
Symptom Management Alternatives
|
Non-pharmacologic and pregnancy-safe treatments for nausea, anxiety,
and sleep
|
Supports abstinence
|
Address perceived medical use of cannabis
|
|
Partner and Social Environment Interventions
|
Address partner use; promote a cannabis-free home
|
Reduces continued use and relapse
|
Support family-inclusive counseling
|
|
Postpartum Relapse Prevention
|
Continued screening, mental health support, and breastfeeding
counselling
|
Reduces resumption of use
|
Cannabis is discouraged during breastfeeding
|
|
Trauma and Violence-Informed Care
|
Respectful, stigma-free approach
|
Improves disclosure and adherence
|
Critical component
|
For more information, see SOGC Guideline No. 425b: Cannabis Use Throughout Women’s Lifespans Part 2:Pregnancy, the Postnatal Period, and Breastfeeding.
Opioids
Opioid use disorder requires stabilization and coordinated, multidisciplinary
care prior to conception. Abrupt cessation is not recommended; opioid agonist
therapy improves maternal and neonatal outcomes. Preconception planning allows
optimization of dosing, relapse prevention strategies, and integration of
addiction, primary care, and mental health services.
Key Preconception Actions
- Screen for opioid use disorder
- Continue or initiate opioid agonist therapy (OAT) when indicated
- Coordinate addiction medicine care
- Provide overdose prevention supports
- Integrate mental health services
Clinical Pearl: Opioid agonist therapy (methadone or
buprenorphine) improves maternal and neonatal outcomes.
Summary of Opioid Use Interventions in Pregnancy
|
Intervention Category
|
Key Components
|
Evidence and Effectiveness
|
Clinical Considerations
|
|
Universal Screening (Core Intervention)
|
Routine screening for prescribed and non-prescribed opioid use;
validated tools (4Ps, NIDA, CRAFFT)
|
Improves early identification and engagement
|
Universal, trauma-informed screening
|
|
Brief Counselling and Education
|
Nonjudgmental counselling; education on risks and treatment options
|
Improves treatment uptake
|
Emphasize the safety of treatment over abstinence
|
|
Motivational Interviewing (MI)
|
Explore ambivalence; build trust and autonomy
|
Effective for engagement in care
|
Recommended for hesitancy or fear of disclosure
|
|
Preconception Counseling
|
Optimize health; review opioid and pain management; plan pregnancy
|
Reduces early pregnancy risks
|
Support preconception stabilization
|
|
Opioid Agonist Therapy (OAT)
|
Methadone or buprenorphine maintenance
|
Strong evidence for improved maternal and neonatal outcomes
|
First-line, standard of care in pregnancy
|
|
Medically Supervised Withdrawal
|
Tapering or detoxification
|
High relapse and fetal risk
|
Not recommended
|
|
Pharmacotherapy Safety
|
Methadone/buprenorphine; naloxone access
|
Benefits outweigh risks
|
Safe in pregnancy and breastfeeding
|
|
Integrated Multidisciplinary Care
|
Obstetrics, addiction, mental health, and social services
|
Improves retention and outcomes
|
Strongly encouraged
|
|
Partner and Social Support Interventions
|
Address partner use; assess social determinants
|
Supports sustained engagement
|
Trauma-informed, family-inclusive approach
|
|
Postpartum Relapse and Overdose Prevention
|
Continued OAT; mental health care; naloxone; breastfeeding support
|
Reduces relapse, overdose, and NOWS severity
|
Critical postpartum focus
|
For more information, see SOGCGuideline No. 443b: Opioid Use Throughout Women’s Lifespan: OpioidUse in Pregnancy and Breastfeeding.
Clinical Pearl: Opioid Agonist Therapy Is Safer Than Withdrawal. Methadone or buprenorphine improves outcomes. Abrupt cessation increases
relapse and overdose risk.
Stimulants (e.g., methamphetamine, cocaine)
Stimulant use is associated with cardiovascular strain, placental
complications, and fetal growth restriction. Preconception care should
prioritize stabilization, harm reduction, and assessment of co-occurring
social and medical risks. Addressing housing instability, intimate partner
violence, and nutrition before conception can meaningfully improve outcomes.
Key Preconception Actions
- Assess pattern of use
- Address polysubstance exposure
- Screen for cardiovascular risk
- Stabilize sleep, nutrition, and housing where possible
- Coordinate addiction services
Clinical Pearl: Addressing social determinants such as
housing and nutrition can significantly improve outcomes.
For more information, see SOGC Guideline No. 349-Substance Use in Pregnancy.